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Mechanistically, two major NETosis phenotypes have been delineated: (1) Suicidal NETosis, a slower and oxidant-dependent pathway that culminates in plasma membrane rupture and neutrophil death, and (2) Vital NETosis, a rapid, non-lytic process in which neutrophils remain functionally active, capable of migration, phagocytosis, and cytokine secretion following NET release [47]

Zepbound is produced by a single manufacturer in specific, pre-filled auto-injector pens, and the high demand has frequently exceeded their production capacity