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A bibliographic search in MEDLINE/PubMed was carried out to collect clinical and pre-clinical research or review articles on EDs, and their main ingredients (caffeine, taurine, etc.), from 1987 to September 2022

The market offers a range of options across powder mixes, liquid drops, and comprehensive blends

Stress spikes glutamate, suppresses astrocyte activity, and eats up GABA

No dose adjustment is required in renal impairment according to the UK SmPC, though renal function should be monitored, especially if significant gastrointestinal adverse effects or dehydration occur

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