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16S rRNA sequencing showed that excessive APAP significantly changed the composition and diversity of gut microbiota, including increasing the ratio of Firmicutes / Bacteroidetes and reducing the abundance of Proteobacteria , Roseburia , Lactobacillus , Akkermansia muciniphila and Saccharomyces cerevisiae ( 81)

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Digestive issues during opioid withdrawal can lead to dehydration Nausea, diarrhea, and a lack of appetite are common during withdrawal