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[2] It is the main and most common cause of vitamin B 12 deficiency anemia in developed countries, [3] and is characterized by a triad of symptoms: [2] Anemia with bone marrow promegaloblastosis (megaloblastic anemia)

Plasma concentrations measure approximately 200 ng/mL at age 20 and decline to approximately 80 ng/mL by age 60

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Further research is needed with aging, fit, healthy subjects, measuring a variety of physiologic and metabolic endpoints to determine if the results of this case study prevail, and if so, the mechanism of any such benefits achieved

9 , R66 (2007)