Orlov, Nikolai L
Those with asthma should be particularly cautious with NAC, as it may trigger bronchospasm in some sensitive individuals
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Unfortunately, for some people, this can result in super negative side effects like nausea, vomiting, and diarrhea - one study reported that 50% of patients taking GLP-1 agonists experienced nausea while taking them
And then secondly, you're really hindered by the idea that you're studying that animal in an artificial environment and when you reduce the risk of a subset of death, a subset of causes of death which is effectively metabolic disease, you're often unable to measure what in my opinion is an underappreciated risk that comes on, which is, sort of, the more sudden and traumatic causes of death that we take for granted, especially in the case of caloric restriction