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With no further research available at the moment, there is insufficient evidence to recommend B12 for sleep rhythm disorders

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Migration inhibitory factor (MIF) Macrophage migration inhibitory factor (MIF) is a multipotent pro-inflammatory cytokine found in activated T lymphocytes and macrophages/monocytes, initially reported to be mainly involved in the innate and adaptive immune responses

Antioxid Redox Signal 18: 2106- 2121 Rahantaniaina MS, Li S, Chatel-Innocenti G, Tuzet A, Issakidis-Bourguet E, Mhamdi A, Noctor G (2017) Cytosolic and chloroplastic DHARs cooperate in oxidative stress-driven activation of the salicylic acid pathway