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Cell Physiol Biochem 43:852869 Arensdorf AM, Dillard ME, Menke JM et al (2017) Sonic hedgehog activates phospholipase A2 to enhance smoothened ciliary translocation

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Because this detoxification pathway relies heavily on glutathione, a deficiency means that histamine remains circulating in the bloodstream for prolonged periods

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Moreover, CHIP was found to be common in patients with dyskeratosis congenita, a disease resulting from mutation in TL maintenance genes, including those that encode telomerase subunits and thereby causing critically short telomeres