The most frequent adverse effects are gastrointestinal and dose-related: Nausea, vomiting, diarrhoea, constipation, and abdominal discomfort - Typically worst during dose escalation and often resolve or attenuate with continued treatment and slower titration
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It also enhances insulin sensitivity and regulates blood sugar levels, leading to improved metabolic health and weight control
Sources Mass General Advances in Motion Preserving Lean Body Mass in Patients Taking GLP-1 for Weight Loss (June 6, 2025) American Diabetes Association New GLP-1 Therapies Enhance Quality of Weight Loss by Improving Muscle Preservation (Press Release, June 23, 2025) UCLA Health Semaglutide for weight loss what you need to know (January 12, 2023) Sokary S., Bawadi H