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Patients with PAH have lower transcriptional levels of GPX3 in lung tissues, identifying GPX3 as a hypoxia-induced metabolism-associated hub gene, which could provide insight into the molecular mechanisms of hypoxic PAH and potential therapeutic targets [108]

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Cocaine binds with high affinity to the norepinephrine transporter (NET) on the presynaptic nerve terminal (Kd 0.3 M), acting as a transmembrane physical plug that inhibits reuptake of norepinephrine

So, AOD 9604 should be viewed as a tool for studying metabolism, not as a weight loss treatment