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It is secreted by various tissues, with the liver being the primary source, releasing IGF-1 into the bloodstream to act as an endocrine hormone
Cellular senescence, i.e., the aging of a particular cell type, is one hallmark of aging and has been categorized as an antagonistic mechanism
Values are presented as the mean standard deviation (SD) and as the minimum/median/maximum
J Strength Cond Res 29(3):786792 Wax B, Kavazis AN, Luckett W (2016) Effects of supplemental citrulline-malate ingestion on blood lactate, cardiovascular dynamics, and resistance exercise performance in trained males