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Both GIPR-Ab/P1 and GIPR-Ab/P2 maintained robust GIPR antagonistic actions on both human and monkey-derived GIPRs, with IC50 values comparable to the original GIPR antibody, indicating that chemical conjugation did not diminish the GIPR antagonistic activity

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A spokesperson for Novo Nordisk, which makes Ozempic and Wegovy, said: Pregnancy or intention to become pregnant were exclusion criteria in our trials with semaglutide in both obesity and type 2 diabetes

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