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It found that while participants lost significant weight (average 17.3 kg), the average reduction in lean mass was 6.9 kg, representing about 40% of the total weight loss

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Furthermore, researchers are exploring combinations of triple agonists with other molecules, such as amylin analogs or myostatin-activin pathway inhibitors, to further refine body composition outcomes and ensure that weight loss is primarily derived from fat mass rather than lean tissue