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Unlike oral supplements that have to go through the digestive system before reaching the bloodstream, a vitamin B12 injection delivers the nutrient directly into the blood
Thus, the exact mechanisms of L-glutamine in reducing the frequency of painful VOC is unknown and this is limiting the further development to improve the formulation for better efficacy of the agent
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(2012)
In melasma, the mean reduction of the modified MASI (mMASI) by treatment with a broad-spectrum sunscreen and topical 4% HQ is expected to be 3040% after 8 weeks and 4555% after 16 weeks [30, 31]
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