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doi: 10.1007/s00198-026-07861-6

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Five of these trials have shown superiority in reducing MACE compared to placebo, while all have confirmed the cardiovascular safety of GLP-1 RAs ( 4.3.1 Cardiovascular outcomes in GLP-1 RAs studies The ELIXA trial, which included 6068 patients, was the first to investigate the cardiovascular effects of GLP-1 RAs