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Transitioning to FDA-approved medications, exploring older weight-loss options, and focusing on lifestyle changes can all contribute to sustained success

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For patients without pre-existing gallstones, no the evidence does not support routine prophylactic cholecystectomy before starting GLP-1 therapy

Fecal microbiota transplantation (FMT) from healthy donors to individuals diagnosed with metabolic syndrome, delivered via duodenal infusion, has been shown to alter the gut microbial profile of recipients and enhance insulin sensitivity (134)