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They also function to disrupt the positive feedback mechanism involving local prostaglandin production that is responsible for further increasing estrogen levels in ectopic endometrial cells (34)

If nausea is persistent or severe enough to consistently prevent eating or drinking, it is worth mentioning to a healthcare provider, who may adjust the dose or suggest additional strategies

Most programs, including physician-led ones in Georgia, follow guidelines from the Obesity Medicine Association and the FDAs approval criteria

Clinical trials of GLP-1 medications, including the STEP program for semaglutide and SURMOUNT trials for tirzepatide, have documented improvements in physical function scores and quality of life measures