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Approximately 25% of children who undergo Nissen Fundoplication experience post-prandial hypoglycemia ( Children with post-prandial hypoglycemia after Nissen fundoplication exhibit higher GLP-1 and insulin plasma concentrations, and lower plasma glucose nadir in response to an oral glucose tolerance test than controls

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In some embodiments, the otic formulation or composition comprises about 0.07% by weight of the carbomer

This was still far below the results seen with surgery