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Providers should assess thyroid function, screen for medullary thyroid cancer history, evaluate kidney and cardiovascular status, and document any gastroparesis or pancreatitis history

According to NBC News, the third phase of the clinical trial found that people with osteoarthritis who dieted, exercised, and took semaglutide the blockbuster drug sold by Novo Nordisk as Ozempic and Wegovy lost more weight and reported a greater reduction in knee pain than those who lost weight with just diet and exercise. The study included roughly 400 patients with knee osteoarthritis, 80% being women, who experience osteoarthritis at higher rates than men, according to NBC News

This bidirectional modulation gives the compound a homeostatic quality: it pushes tissue toward repair rather than simply amplifying any single pathway