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Oncogene 40 , 22172229 (2021)

Patients on tirzepatide often report needing more sleep initially as their bodies adjust to lower calorie intake and metabolic changes

Researchers observed marked differences in the expression levels of GPER in different types of thyroid tissues, particularly in comparisons between benign and malignant thyroid tumors, with relatively low GPER expression levels in malignant tumors, further emphasizing the potential role of GPER in thyroid diseases [206]

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In this pathway, oxidative stress can trigger the release of cytochrome c from mitochondria into the cytosol