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The protein samples (40 g) were separated by 10 % SDS-polyacrylamide gel (Beyotime, Shanghai, China) electrophoresis and transferred to PVDF membranes

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This multi-receptor activation differentiates retatrutide from monotherapy and dual-agonist compounds, positioning it as a significant research tool for investigating metabolic disorders

Conclusions The therapeutic scope of GLP-1R agonists is expanding beyond traditional metabolic targets, highlighting its potential for headache and pain disorders

Cornier, who has received compensation from Novo Nordisk for serving as a consultant, echoed some of Banks concerns