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The activated NF- B rapidly translocated from the cytoplasm into the nucleus, binds to specific DNA sequences, induces the expression of several proinflammatory cytokine genes, and promotes the massive release of proinflammatory cytokines such as TNF- , IL-1, and IL-6 (Xu et al., 2022)

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Phosphoenol Pyruvate Carboxylase (PEPC) catalyses the reaction between phosphoenol pyruvate and carbondioxide (bicarbonate) to form oxaloacetate and phosphate ion