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Both subcutaneously and intravenously administered glucagon-like peptide 1 are rapidly degraded from the NH2-terminus in type II diabetic patients and in healthy subjects

Lack of Human PK/PD : There are no published human clinical trials defining the optimal therapeutic dose (TD) or minimal effective dose (MED) for either peptide in humans [2]

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The hypercoagulable state is due in part to immune system dysregulation, inflammation and endothelial cell damage, as well as a reduction in defense systems

However, among phase-variable genes, genes involved in a broad spectrum of other metabolic functions were found