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All three medications are generally safe and well tolerated

An A1298C mutation is associated with neurotransmitter balance which has implications for mood regulation, depression, and addiction (6)

The first screening of publications was carried out based on the titles and abstracts

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Teva (and other manufacturers) maintained exclusivity through the shift from chlorofluorocarbon (CFC) propellants to hydrofluoroalkane (HFA) propellants a formulation change mandated by the Montreal Protocol that required new NDAs and created new patent opportunities for the HFA formulation