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Through downregulating monocyte chemoattractant protein-1 expression, semaglutide treatment, an FDA-approved GLP-1 RA medicine targeting Type II diabetes mellitus (T2DM) (Christou et al., 2019), inhibited monocyte migration and infiltration from the circulatory system to inflammatory regions (Pontes-da-Silva et al., 2022)

The NHS or private healthcare providers cannot currently prescribe it

They can help you safely adjust or discontinue treatment while monitoring for any withdrawal effects

You may be unsuitable for this slimming injection if you: Have any known allergies to ingredients in it Are breastfeeding, pregnant or planning to conceive Are over 75 years old or under 18 years Have severe heart failure Have diabetes and currently take other medications containing GLP-1 (lixisenatide or exenatide) or have hypoglycaemia (low blood sugar) Have severe gut or stomach problems like inflammatory bowel disease or gastroparesis (delayed stomach emptying) Have severe kidney or liver disease or on dialysis Ensure you mention to your weight loss doctor the following conditions: Pancreatic diseases Diabetes Gallstones or inflamed gallbladder A racing heart or heart palpitations Thyroid diseases, including enlargement of the thyroid gland and thyroid nodules Mild to moderate kidney or liver disease A condition requiring you to take anticoagulants such as warfarin Inflamed gallstones or gallbladder Included in our protocol, is screening for the above, so when you access our service, we will assess you to ensure safety of these medications

Nat Med 22:8490