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Advances in metabolomics and nutrigenomics suggest that specific patient subpopulations may realize the greatest benefit, indicating a move away from generalized supplementation toward a more targeted adjunctive therapy integrated with evidence-based cardiovascular care (Figure 1), distinguishing well-established clinical evidence from hypothesis-generating findings, and highlights emergent areas where nutraceuticals may reshape preventive and therapeutic cardiology

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2) Persistent gastrointestinal symptoms in women, as abdominal pain, altered bowel habits, or gastrointestinal bleeding, especially with cyclical nature, warrant thorough evaulation including radiological and endoscopic examination with histopathology

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