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While incretin signaling improves glycemic control and inflammatory tone, sustained hypophagia shifts the locus of metabolic regulation toward substrate availability and metabolic throughput

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Endocrine (2020) 70:2928

Sleep-related impairment (SRI) refers to cognitive, emotional, and functional disturbances caused by insufficient or low-quality sleep, including daytime fatigue, decreased concentration, and diminished work performance [143]

This information helps your provider decide whether to maintain the current dose or begin dose escalation at the next scheduled adjustment