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Combinations are listed for research context only and do not imply safety or efficacy in humans

The present study emulated a target trial to avoid immortal time and selection bias, chose a second-line glucose-lowering therapy as an active comparator to reduce confounding by indication, used an outcome definition based only on primary care records to minimize detection bias due to differential hospitalizations, and implemented a lag time to mitigate bias due to reverse causality

doi: 10.1074/jbc.M804372200 31 FourtnerSHStanleyCAKellyA