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We previously established a procedure to induce human embryonic stem cells (hESCs) to differentiate into cardiomyocytes ( 2 Materials and methods 2.1 Cardiomyocyte generation and treatment Cardiomyocytes were differentiated from hESCs (H1 cell line)

Interestingly, the insulin/IGF-1 pathway displays an antagonistic pleiotropy with aging, i.e., during development insulin/IGF-1 signaling has fundamental functions in cellular differentiation and the growth of animals, whereas later in the life, it regulates metabolism but its activity clearly accelerates the aging process [1, 2]

doi: 10.1016/j.ajpath.2024.03.014 132 ZhengKYangLZhangRSQianYHZhouYGHuangWFet al

No long-term safety registry exists for repeated glutathione exposure in non-clinical populations, and interactions with medications are not fully characterized