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ii) Utilizing the steric hindrance conferred by dimerization reduces protease access to the active site and significantly improving stability against proteases 49,50

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The compound retains full GHRH receptor agonist activity despite lacking the C-terminal 15 residues of native GHRH, making it the shortest GHRH fragment with documented full intrinsic efficacy at the pituitary GHRH receptor (GHRHR)

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