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The SURMOUNT-4 trial assessed the weight maintenance with tirzepatide and had also two periods: a 36-week open-label lead-in period during which all participants took tirzepatide, followed by a 52-week double-blind treatment period during which participants were randomised to either continue on tirzepatide or switch to placebo

introducing harmonised release criteria linked to paracrine bioactivity is essential if multicentre trials are to generate pooled datasets

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doi: 10.3390/encyclopedia2020063, 43

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