They work through overlapping but distinct mechanisms, and retatrutide has shown higher weight loss in trials so far
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It names body composition, age, and inflammatory phenotype, and singles out people with inflammatory conditions, obesity-related lipohypertrophy, or those taking anti-inflammatory medications as likely to see different local reactions
A clustering of contamination events or persistent post-inflammatory hyperpigmentation cases tied to specific at-home protocols would shift the recommendation toward more conservative cadence or stricter contraindication screening
The HPA axis normally triggers cortisol release during stress, but chronic activation leads to elevated baseline cortisol, which is linked to weight gain, inflammation, and metabolic dysfunction