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Preparation and pharmacokinetics of docetaxel based on nanostructured lipid carriers

Abbreviations ApoB: Apolipoprotein B ApoC3: Apolipoprotein C3 ANCOVA: Analysis of covariance BMI: Body mass index CI: Confidence interval CV: Cardiovascular CVD: Cardiovascular disease CVOT: Cardiovascular outcome trials DBP: Diastolic blood pressure GLP-1RAs: Glucagon-like peptide 1 receptor agonists HbA1c: Glycated haemoglobin HDL: High-density lipoprotein hsCRP: High-sensitivity C-reactive protein IL-6: Interleukin-6 LCMS/MS: Liquid chromatography- tandem mass spectrometry LDL: Low-density lipoprotein LSM: Least squares mean MACE: Major adverse cardiovascular events mITT: Modified intent-to-treat MMRM: Mixed model repeated measures NT-pro-BNP: N-terminal pro-type natriuretic peptide N: Number of randomized participants PBO: Placebo OFG: Orforglipron RCT: Randomized Clinical Trial SBP: Systolic blood pressure SD: Standard deviation SE: Standard error T2D: Type 2 Diabetes VLDL: Very low-density lipoprotein References Ma CX, Ma XN, Guan CH, Li YD, Mauricio D, Fu SB

too little may not offer the desired therapeutic benefit