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The latter typically occurs when reactive oxygen species, also known as harmful byproducts of metabolism, accumulate and affect DNA, proteins and lipids

Funding This work was supported by the National Natural Science Foundation (Grant numbers 82170340, 82000333, 82200376, and 82070320)

AA received research grants and lecture or advisory board fees from MSD, AstraZeneca, Novartis, Boehringer Ingelheim, Sanofi, Mediolanum, Janssen, Novo Nordisk, Lilly, Servier and Takeda

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