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Generally, weight loss of greater than 24% of initial body weight and at a rate greater than 1.5 kg (about 3.3 pounds) per week has been identified as a risk factor for gallstones, but the risk may be mitigated by controlling the rate of weight loss, reducing the length of the overnight fast, and keeping a small amount of fat (at least 7 grams per day) in the diet to improve gallbladder motility (Erlinger 2000)

Patients who received semaglutide, however, reported more gastrointestinal adverse events (AEs)

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