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3.5.2 Effect of UPF on the increased risk of food addiction The consumption of UPF was significantly associated with FA (91, 123, 135), and a dose-dependent increase in FA risk (123) (Table 2)

ACSL4 plays an important role in PUFA activation and determines ferroptosis sensitivity (Shin et al., 2018)

Mutations in these genes not only cause severe obesity but also frequently lead to a broad spectrum of neurological phenotypes, including intellectual disability, developmental delay, and behavioral abnormalities (e.g., autism-like features), highlighting the foundational role of hypothalamic development in energy homeostasis [12,14]

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