A high percentage of cells in S-phase is associated with a better clinical response to MTX ( TYMS , CPTS , and an MTX target enzyme, DHFR ( via AMPK activation ( In parallel with MTXs most well-known targets, several NAD+-dependent enzymes were inhibited by the antifolate in vitro : 2-oxoglutarate, isocitrate, malate, pyruvate, succinate, 6-phosphogluconate and glucose-6-phosphate dehydrogenases, glutamate-cysteine ligase, glutathione reductase, and glutathione peroxidase ( in vitro and in vivo , resulting in decreased levels of S-adenosylmethionine (SAM) ( Despite the number and importance of such enzymes to cellular metabolism, few studies have been conducted to better understand the effects of MTX on cellular metabolic homeostasis or find metabolic fragilities that could be exploited clinically
Esto implica: Establecer y mantener un dficit calrico consistente a travs de una dieta equilibrada, rica en nutrientes y controlada en energa, que priorice protenas magras, carbohidratos complejos y grasas saludables
[DOI] [PubMed] [PMC] Rudkowska I, Raymond C, Ponton A, Jacques H, Lavigne C, Holub BJ, et al
10.1093/nar/gkm355 Nucleic Acids Res
How Does the Mechanism of GHK-Cu Translate Across Injectable and Topical Routes
