Aleksandrova, L
As we know, the GLP1a drugs bind to and activate the GLP1 receptor, causing a range of effects, including increased insulin secretion, glucagon suppression and slowed gastric emptying
Antibodies targeting IL1- have also shown mixed, although more positive effects, particularly in reducing HbA1c with IL1- antagonism [206], with recent evidence suggesting that combined TNF-alpha and IL1- blockade may be most effective for glycemic control [207]
The direct regulation of GLP-1 on insulin expression is significant for type 2 diabetes (T2D) patients with simple glucose tolerance but normal insulin secretion ( 2 Peptide-based GLP-1 derivatives and small molecule compounds of GLP-1RA There are two main categories of GLP-1 receptor agonists, small molecule compounds and peptide-based GLP-1 derivatives as shown in Figure 1 , including exenatide, liraglutide, dulaglutide, etc
Numerous research data described possible cardioprotective effects by causing vasorelaxation and the moderation of certain pathological conditions of cardiovascular diseases, including cardiac hypertrophy, platelet aggregation, angiogenesis, and metabolic disorders such as hyperlipidemia or hyperglycemia [228, 229]