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Practical readouts to separate signalling from damage Practical readouts to separate signalling from damage combine signalling proxiessuch as reversible cysteine oxidation mapped by redox proteomics, the redox state of peroxiredoxins as fast cycling sentinels, compartment-targeted H 2 O 2 reporters that resolve matrix/ER/PM microdomains and phospho-signatures downstream of redox-sensitive kinaseswith damage proxies including lipid-peroxidation adducts, protein carbonyls or nitrotyrosine, DNA oxidation and strand breaks and indices of bioenergetic failure (Garrido Ruiz et al

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PMID: 35949360

Hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated using Cox proportional hazards regression models