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Repeated-measure analyses of the primary and secondary outcomes at the six assessment time points were conducted with mixed-effects models using all available data, with fixed effects for treatment, visit, baseline weight, type of surgery, sex and diabetes status (and for secondary outcomes, the baseline value for the secondary outcome), an interaction term between treatment and visit, and a random intercept for participant

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Current large-scale human studies and "real-world" data involving tens of thousands of patients have, thus far, not shown a significant increase in thyroid cancer among humans taking semaglutide

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