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By eating smaller meals and not snacking between meals, you are creating a calorie deficit

Blood 100:765a, 2002

More aggressive weight loss goals may make tirzepatide a preferred option, while moderate goals may suit semaglutide

In turn, these proliferating synovial cells release pro-inflammatory mediators that stimulate the expression of matrix-degrading enzymes and other catabolic factors (Hunter and Bierma-Zeinstra, 2019