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The 143B and HOS cell lines were cultured in RPMI 1640 medium supplemented with 10% FBS and 1% P/S

Abnormal cell death, triggered by H 2 O 2 resulting from the catalytic degradation of UA by natural uricase and PDA@Pt, was investigated using the same cytotoxicity assay protocol as mentioned above, with the UA concentration at 1 mM

Researchers assumed that this was probably due to the sulphite formation in the nebulized solution and/or the metabolism of GSH into leukotrienes, potent pro-inflammatory bronchoconstrictors