Figure 14: Diagram showing the contrasting functions of glucagon and insulin, credit: Carogonz11, Wikimedia
For people with type 2 diabetes, insufficient medication doses can lead to poor blood sugar control, potentially causing long-term complications like nerve damage, kidney problems, or cardiovascular issues
While numerous studies have shown the benefits of semaglutide, we often see similar outcomes when patients achieve a healthy weight through other means, such as surgery. Further research into semaglutide and other hormone agonist medications is needed to determine which effects are independent of weight loss, advised Ali
In addition, functional study demonstrated that local injection of GLP-1 into the BNST induces food suppression during the dark phase (Williams et al., 2018)
Semaglutide (Wegovy): STEP-1 trial The once-weekly injectable semaglutide 2.4 mg is currently the market leader for pharmacologic weight management