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Autism is known to have a strong genetic component, and by comparing siblings, the study was able to control for, or remove, genetic factors and family environment from the equation

Maintenance dosing considerations: Community protocols commonly describe two maintenance approaches after the initial 8-12 week loading phase: (1) reduced frequency at the same dose (e.g., IV once monthly instead of weekly), or (2) transitioning from injectable/IV to high-bioavailability oral (liposomal) for convenience while accepting a modest reduction in peak levels

2019;33(S1) 814.3-.3 Dintaman JM, Silverman JA

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Additionally, Rybelsus acts on receptors in the brain that regulate appetite and satiety, which can contribute to feelings of queasiness, especially during the initial treatment period