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methyl-B12, 25 mg daily for 10 days followed by 25 mg monthly for 5 months

Among the more potent compounds were the racemic pyridine derivative 37 (HFI-419), and the quinoline derivatives 38 (HFI-435) and 39 (HFI-437) exhibiting K i values of 420, 360, and 20 nM, respectively (Figure 9)

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Ad-ditionally, SIN diminishes the unusually elevated expression of 7nAChR through the 7nAChR/ERK/Egr-1 feedback process, thus hindering M1 polarization in macrophages and reducing inflammation (94)

(primary author) accessed 23-Aug-2013