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5.2 Pathway-Specific Approaches in Genetic PD GBA1-variant associated PD is the most common genetic PD subtype and overall has an earlier age of onset, faster progression and greater risk for cognitive decline as well as generally greater NMS burden [190]

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Lixisenatide showed disease-modifying effects in the LIXIPARK trial by stabilizing motor symptoms in early PD [36]

The relevant study also found that the 1-year average weight loss of participants (LIR 3.0 mg) was 9.2 kg reporting nausea/vomiting episodes, while that of participants without nausea/vomiting was 6.3 kg