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Medically reviewed by Jillian Foglesong Stabile, MD, FAAFP

Tirzepatide helps manage hunger and blood sugar, but the quality of your nutrition and physical activity still matters

However, with direct injection, if you do not need the additional B12, it may result in high levels in your blood that can cause side effects including gastrointestinal issues, headache and dizziness, tiredness and weakness, or skin irritation until the excess is flushed out via your kidneys and urine

Vitamin B-12 supplementation during pregnancy and early lactation increases maternal, breast milk, and infant measures of vitamin B-12 status

A typical pattern involves 6-8 weeks on followed by 4-8 weeks off before considering another cycle if needed