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The DIO and control mice were housed 46 mice per cage

Senescence-associated 13-HODE production promotes age-related liver steatosis by directly inhibiting catalase activity

But its limitations are significant

consequently, reduced or temporally/spatially mismatched Treg-derived cytokines (TGF-, IL-10, and IL-35) can weaken mucosal tolerance and reparative programs, whereas context-dependent Treg overexpansion may impair antimicrobial immunity, resulting in dysregulated intestinal homeostasis 50,51