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Beyond the liver, alcohol administration disturbs lipid homeostasis within adipose tissue, triggering a pathological flux of FFA from peripheral fat depots to the liver (Zhong et al., 2012

was supported by a Wellcome Trust Senior Investigator Award (WT098424AIA), MRC Program grants (MR/J0003042/1, MR/L020149/1) and Experimental Challenge Grant (DIVA, MR/L02036X/1), BBSRC (BB/J015873/1), MRC (MR/N00275X/1), Diabetes UK (BDA/11/0004210, BDA/15/0005275, BDA 16/0005485) and Imperial Confidence in Concept (ICiC) grants, and a Royal Society Wolfson Research Merit Award

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There was a non-significant trend toward greater tumor response in melatonin-treated patients as well (11 of 34 vs