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In August 2025, accelerated approval was granted for treating noncirrhotic MASH with F2F3 fibrosis, contingent on confirmatory ESSENCE outcomes

The astrocyte response in experimental portal-systemic encephalopathy: an electron microscopic study

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Kidney Int 99(4):828840 Clemente-Surez VJ, Redondo-Flrez L, Beltrn-Velasco AI, Ramos-Campo DJ, Belinchn-deMiguel P, Martinez-Guardado I et al (2023) Mitochondria and brain disease: a comprehensive review of pathological mechanisms and therapeutic opportunities

This gives the body more time to adjust to the medicine