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The role of the inflammatory foam cells (so-called because theyre so packed with cholesterol they look foamy under a microscope) affected by TMAO is explained in my video series that begins with Arterial Acne, and continues in Blocking the First Step of Heart Disease

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Notably, mitochondrial dysfunction is closely linked to NLRP3 inflammasome activationbone marrow-derived macrophages deficient in Lcn2 exhibit reduced mitochondrial damage, accompanied by diminished NLRP3 activation and decreased IL-1 production [126]

CPI came in at 4.2% in May 2026, pushing the real yield on the 10-year T-note down to just 0.36%